| Autor: |
Glória Maria De França, Andréia Ferreira do Carmo, Hugo Costa Neto, Ana Luiza Dias Leite de Andrade, Kenio Costa de Lima, Hébel Cavalcanti Galvão |
| Jazyk: |
angličtina |
| Předmět: |
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| Zdroj: |
Brazilian Oral Research, Vol 33, Iss 0 |
| Druh dokumentu: |
article |
| ISSN: |
1807-3107 |
| DOI: |
10.1590/1807-3107bor-2019.vol33.0047 |
| Popis: |
Abstract: The aim of this study was to evaluate macrophage M1 and M2 subpopulations in radicular cysts (RCs) and periapical granulomas (PGs) and relate them to clinical and morphological aspects. M1 macrophages were evaluated by the percentage of CD68 immunostaining associated with the inflammatory cytokine TNF-α, and M2 macrophages, by its specific CD163 antibody. The CD68+/CD163+ ratio was adopted to distinguish between the two macrophage subpopulations. Clinical, radiographic, symptomatology, treatment, and morphological parameters of lesions were collected and a significance level of p = 0.05 was adopted for statistical analysis. The results showed that the CD68+/CD163+ ratio was higher in the RCs (median = 1.22, p = 0.002), and the highest TNF-α immunostaining scores were found in RCs (p = 0.018); in PGs, the CD68+/CD163+ ratio was lower and associated with a greater CD163+ immunostaining (median = 1.02, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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