| Autor: |
Alberto Baldelli, Hashem Etayash, Hale Oguzlu, Ronit Mandal, Feng Jiang, Robert E.W. Hancock, Anubhav Pratap-Singh |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Chemical Engineering Journal Advances, Vol 10, Iss , Pp 100273- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2666-8211 |
| DOI: |
10.1016/j.ceja.2022.100273 |
| Popis: |
Spray-dried nanoparticle-in-microsphere formulations, composed of aluminum oxide nanoparticles (NPs), zinc oxide, zinc oxide NPs and cellulose nanocrystals (CNCs), with potent antimicrobial and antibiofilm activity against Gram-negative and Gram-positive bacteria are reported. The study highlights the role of matrix compositions (ratios) in manipulating metal oxide biomaterials' antimicrobial properties and toxicity. The antimicrobial activity of nanoparticle-in-microsphere was higher than each raw material used. A formulation composed of CNCs (weight % ≥ 0.75%) and an equal weight % of aluminum oxide and zinc oxide NPs (∼ 0.25% per type of NPs) produced the highest antimicrobial and antibiofilm activity. Interestingly, the toxicity of these formulations, tested against peripheral blood mononuclear cells, was very minimal (≤500 µg/ml) and significantly lower than the toxicity of the metal oxide NPs when tested alone. Nanoparticles-in-microspheres with low toxicity and high antimicrobial properties could be employed in target drug delivery to bypass antibiotics. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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