Farrerol directly activates the deubiqutinase UCHL3 to promote DNA repair and reprogramming when mediated by somatic cell nuclear transfer

Autor: Weina Zhang, Mingzhu Wang, Zhiwei Song, Qianzheng Fu, Jiayu Chen, Weitao Zhang, Shuai Gao, Xiaoxiang Sun, Guang Yang, Qiang Zhang, Jiaqing Yang, Huanyin Tang, Haiyan Wang, Xiaochen Kou, Hong Wang, Zhiyong Mao, Xiaojun Xu, Shaorong Gao, Ying Jiang
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-023-37576-9
Popis: Here the authors find that farrerol directly binds to UCHL3 and activates its deubiquitinase activity, and that farrerol promotes development of SCNT embryos by enhancing HR repair and restoring epigenetic networks in a UCHL3-dependent manner.
Databáze: Directory of Open Access Journals
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