Losartan Inhibits Nuclear Factor-κB Activation Induced by Small, Dense LDL Cholesterol Particles in Human Umbilical Vein Endothelial Cells
| Autor: | Gonghui Guo, MM, Xiaojing Cheng, MM, Rong Fu, MM |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Current Therapeutic Research, Vol 76, Iss C, Pp 17-20 (2014) |
| Druh dokumentu: | article |
| ISSN: | 0011-393X 1879-0313 |
| DOI: | 10.1016/j.curtheres.2013.11.006 |
| Popis: | Objective: We aimed to investigate how losartan exerts protective effects on human umbilical vein endothelial cell injury induced by small, dense, LDL (sLDL) cholesterol particles. Methods: sLDL cholesterol was isolated by a 2-steps method and the nuclear translocation and activation of nuclear factor-κB (NF-κB) in endothelial cells was observed by confocal microscopy and electrophoretic mobility shift assays. Results: Losartan greatly inhibited the nuclear translocation of NF-κB induced by sLDL cholesterol in a dose-dependent manner. Conclusions: sLDL cholesterol may be involved in endothelial dysfunction possibly through NF-κB activation; losartan protects against sLDL cholesterol-inducing endothelial cell injury by inhibiting NF-κB activation, suggesting that losartan may play a role in the prevention and treatment of cardiovascular disease. |
| Databáze: | Directory of Open Access Journals |
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