FUNCTIONAL STATE OF MYOCARDIUM AFTER APPLICATION OF A NON-CELLULAR ALLOGENIC MATERIAL FOR STIMULATION OF REGENERATION CAPACITY IN EXPERIMENTAL INFARCTION
| Autor: | S. A. Afanasiev, D. S. Kondratieva, A. I. Lebedeva, S. A. Muslimov, S. V. Popov |
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| Jazyk: | ruština |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Российский кардиологический журнал, Vol 0, Iss 3, Pp 71-75 (2018) |
| Druh dokumentu: | article |
| ISSN: | 1560-4071 2618-7620 59224398 |
| DOI: | 10.15829/1560-4071-2018-3-71-75 |
| Popis: | Aim. Evaluation of influence of the stimulated regeneration abilities of myocardium with non-cellular allogenic material (NAM) on contractility restoration in experimental post-infarction remodelling.Material and methods. The experiment was done on the Wistar rodents with postinfarction cardiosclerosis (PICS), and PICS rodents post injection of the NAM at the moment of coronary artery stenosing. PICS was being formed during 45 days after coronary occlusion. The assessments were the formation and size of postinfarction scar of the left ventricle in rodents of different groups. Myocardial contractility was assessed by inotropic reaction of isolated papillary muscles on rest periods (4-60 s) with stimulation frequency 0,5 Hz, under conditions of perfusion with oxygnated Krebs-Henseleit solution.Results. PICS in the rodents after injection of NAM developed only in 56%, and in comparison group 100%. The size of the scar area was 22% smaller in NAM group (p |
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