CD8+ T lymphocyte is a main source of interferon-gamma production in Takayasu’s arteritis

Autor: Yan-Long Ren, Tao-Tao Li, Wei Cui, Li-Min Zhao, Na Gao, Hua Liao, Jiang-Hui Zhang, Jun-Ming Zhu, Zhi-Yu Qiao, Shi-Chao Guo, Li-Li Pan
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Druh dokumentu: article
ISSN: 2045-2322
DOI: 10.1038/s41598-021-96632-w
Popis: Abstract Interferon-gamma (IFN-γ) is a cytokine involved in the pathogenesis of Takayasu’s arteritis (TAK). However, the source of IFN-γ in TAK patients is not fully clear. We aimed to investigate the source of IFN-γ in TAK. 60 TAK patients and 35 health controls were enrolled. The lymphocyte subsets of peripheral blood were detected by flow cytometry, cytokines were detected by Bio-plex. The correlation among lymphocyte subsets, cytokines and disease activity indexes was analyzed by person correlation. The level of serum IFN-γ in TAK patients was significantly increased (P
Databáze: Directory of Open Access Journals
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