| Autor: |
Yiming FU, Xinyao ZHANG, Xiaojun SHE, Yingwen ZHU, Honglian YANG, Xiujie GAO, Bo FU, Bo CUI |
| Jazyk: |
English<br />Chinese |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
环境与职业医学, Vol 41, Iss 2, Pp 119-124 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2095-9982 |
| DOI: |
10.11836/JEOM23198 |
| Popis: |
BackgroundEnvironmental noise pollution is serious, and there are few studies on the effects of long-term noise exposure during sleep on cognitive function and possible biological clock mechanism. ObjectiveTo explore the cognitive impairment induced by noise exposure during sleep in mice and possible biological clock mechanism, and to provide a theoretical basis for the protection against noise exposure. MethodsTwenty male C57BL/6J mice were randomly divided into a control group and a noise-exposed group, 10 mice in each group. The noise-exposed group was exposed to sleep-period noise using a noise generator for 12 h (08:00–20:00) per day for a total of 30 d. The calibrated noise intensity was set at 90 dB. No intervention was imposed on the control group. At the end of the noise exposure, cognitive function of mice was examined using the new object recognition experiment and the open field test, and the hippocampal tissue damage of mice were evaluated by Nissl staining, ionized calcium binding adaptor molecule 1 (Iba1) immunofluorescence staining, and real-time fluorescence quantitative PCR for inflammatory factors and biological clock genes. Oxidative stress indicators in the hippocampus of mice were also detected by assay kit. ResultsAfter noise exposure during sleep period, the results of new object recognition experiment showed that the discrimination index of mice in the noise-exposed group was 0.06±0.04, which was significantly lower than that of the control group (0.65±0.13) (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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