| Autor: |
Margarita VILLAVEDRA, Julio BATTISTONI, Alberto NIETO |
| Jazyk: |
angličtina |
| Rok vydání: |
1999 |
| Předmět: |
|
| Zdroj: |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 41, Iss 5, Pp 297-303 (1999) |
| Druh dokumentu: |
article |
| ISSN: |
1678-9946 |
| Popis: |
We describe the avidity maturation of IgGs in human toxoplasmosis using sequential serum samples from accidental and natural infections. In accidental cases, avidity increased continuously throughout infection while naturally infected patients showed a different profile. Twenty-five percent of sera from chronic patients having specific IgM positive results could be appropriately classified using exclusively the avidity test data. To take advantage of the potentiality of this technique, antigens recognized by IgG showing steeper avidity maturation were identified using immunoblot with KSCN elution. Two clusters of antigens, in the ranges of 21-24 kDa and 30-33 kDa, were identified as the ones that fulfill the aforementioned avidity characteristics. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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