| Autor: |
Mayu Maeda, Takanori Imai, Ryoko Ishikawa, Toshinori Nakamura, Taro Kamiya, Ayako Kimura, Satoshi Fujita, Kenichi Akashi, Hitomi Tada, Hideaki Morita, Kenji Matsumoto, Toshio Katsunuma |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Allergology International, Vol 70, Iss 2, Pp 223-228 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
1323-8930 |
| DOI: |
10.1016/j.alit.2020.09.011 |
| Popis: |
Background: This study was aimed at evaluating the efficacy and safety of oral immunotherapy (OIT) in children with severe cow's milk allergy. Methods: The subjects comprised 28 children (aged 3–12 years) with allergic symptoms that were induced by ≤ 10 mL of cow's milk in an oral food challenge test (OFC). The subjects were randomly allocated to the treatment group (n = 14) and control group (n = 14); the former received rush immunotherapy for 2 weeks, followed by a gradual increase of cow's milk volume to 100 mL for 1 year, and the latter completely eliminated cow's milk for 1 year. Both groups underwent an OFC with 100 mL of cow's milk after 1 year. Results: The treatment group had significantly higher rates of a negative OFC [7/14 (50%) vs. 0/14 (0%), p 100 mL). Conclusions: The effect of immunotherapy was 50%, but the incidence of adverse events was not low. Further studies focusing on safety is necessary to standardize OIT for cow's milk allergy. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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