The role of mRNA m6A methylation in the nervous system

Autor:	Jiashuo Li, Xinxin Yang, Zhipeng Qi, Yanqi Sang, Yanan Liu, Bin Xu, Wei Liu, Zhaofa Xu, Yu Deng
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Epitranscriptomics N6-methyladenosine (m6A) Methyltransferase Demethylase Binding protein Nervous system Biotechnology TP248.13-248.65 Biology (General) QH301-705.5 Biochemistry QD415-436
Zdroj:	Cell & Bioscience, Vol 9, Iss 1, Pp 1-10 (2019)
Druh dokumentu:	article
ISSN:	2045-3701
DOI:	10.1186/s13578-019-0330-y
Popis:	Abstract Epitranscriptomics, also known as “RNA epigenetics”, is a chemical modification for RNA regulation. Ribonucleic acid (RNA) methylation is considered to be a major discovery following the deoxyribonucleic acid (DNA) and histone methylation. Messenger RNA (mRNA) methylation modification accounts for more than 60% of all RNA modifications and N6-methyladenosine (m6A) is known as one of the most common type of eukaryotic mRNA methylation modifications in current. The m6A modification is a dynamic reversible modification, which can directly or indirectly affect biological processes, such as RNA degradation, translation and splicing, and can play important biological roles in vivo. This article introduces the mRNA m6A methylation modification enzymes and binding proteins, and reviews the research progress and related mechanisms of the role of mRNA m6A methylation in the nervous system from the aspects of neural stem cells, learning and memory, brain development, axon growth and glioblastoma.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/83bb28a8b54d4d0d9b733a4eb4946b1e Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.