| Autor: |
Yoscelina Estrella Martínez-López, Daniel Neri-Rosario, Diego Armando Esquivel-Hernández, Cristian Padron-Manrique, Aarón Vázquez-Jiménez, Jean Paul Sánchez-Castañeda, David Girón-Villalobos, Cristian Mendoza-Ortíz, María de Lourdes Reyes-Escogido, Maria Lola Evia-Viscarra, Alberto Aguilar-Garcia, Osbaldo Resendis-Antonio, Rodolfo Guardado-Mendoza |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-024-60081-y |
| Popis: |
Abstract Lifestyle modifications, metformin, and linagliptin reduce the incidence of type 2 diabetes (T2D) in people with prediabetes. The gut microbiota (GM) may enhance such interventions' efficacy. We determined the effect of linagliptin/metformin (LM) vs metformin (M) on GM composition and its relationship to insulin sensitivity (IS) and pancreatic β-cell function (Pβf) in patients with prediabetes. A cross-sectional study was conducted at different times: basal, six, and twelve months in 167 Mexican adults with prediabetes. These treatments increased the abundance of GM SCFA-producing bacteria M (Fusicatenibacter and Blautia) and LM (Roseburia, Bifidobacterium, and [Eubacterium] hallii group). We performed a mediation analysis with structural equation models (SEM). In conclusion, M and LM therapies improve insulin sensitivity and Pβf in prediabetics. GM is partially associated with these improvements since the SEM models suggest a weak association between specific bacterial genera and improvements in IS and Pβf. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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