Autor: |
Veronica Termopoli, Maurizio Piergiovanni, Davide Ballabio, Viviana Consonni, Emmanuel Cruz Muñoz, Fabio Gosetti |
Jazyk: |
angličtina |
Rok vydání: |
2023 |
Předmět: |
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Zdroj: |
Separations, Vol 10, Iss 2, p 139 (2023) |
Druh dokumentu: |
article |
ISSN: |
2297-8739 |
DOI: |
10.3390/separations10020139 |
Popis: |
Membrane introduction mass spectrometry (MIMS) is a direct mass spectrometry technique used to monitor online chemical systems or quickly quantify trace levels of different groups of compounds in complex matrices without extensive sample preparation steps and chromatographic separation. MIMS utilizes a thin, semi-permeable, and selective membrane that directly connects the sample and the mass spectrometer. The analytes in the sample are pre-concentrated by the membrane depending on their physicochemical properties and directly transferred, using different acceptor phases (gas, liquid or vacuum) to the mass spectrometer. Condensed phase (CP) MIMS use a liquid as a medium, extending the range to new applications to less-volatile compounds that are challenging or unsuitable to gas-phase MIMS. It directly allows the rapid quantification of selected compounds in complex matrices, the online monitoring of chemical reactions (in real-time), as well as in situ measurements. CP-MIMS has expanded beyond the measurement of several organic compounds because of the use of different types of liquid acceptor phases, geometries, dimensions, and mass spectrometers. This review surveys advancements of CP-MIMS and its applications to several molecules and matrices over the past 15 years. |
Databáze: |
Directory of Open Access Journals |
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