| Autor: |
Juliana Guarize, Elena Guerini Rocco, Filippo de Marinis, Giulia Sedda, Luca Bertolaccini, Stefano Maria Donghi, Monica Casiraghi, Clementina Di Tonno, Massimo Barberis, Lorenzo Spaggiari |
| Jazyk: |
English<br />Portuguese |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Jornal Brasileiro de Pneumologia, Vol 47, Iss 4 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
1806-3756 |
| DOI: |
10.36416/1806-3756/e20200584 |
| Popis: |
ABSTRACT Objective: EBUS-TBNA cytological sampling is routinely performed for pathological diagnosis, mediastinal staging, and molecular testing in lung cancer patients. EBUS-TBNA samples are not formally accepted for testing programmed death-ligand 1 (PD-L1) expression. The objective of the study was to compare the feasibility, reproducibility, and accuracy of PD-L1 expression assessment in cytological specimens and histological samples. Methods: We prospectively collected histological (transbronchial forceps biopsy) and cytological (EBUS-TBNA) samples from peribronchial neoplastic lesions during an endoscopic procedure at the same target lesion for the pathological diagnosis and molecular assessment of stage IV non-small cell lung cancer (NSCLC). Results: Fifteen patients underwent the procedure. Adequate cytological samples (at least 100 neoplastic cells) were obtained in 12 cases (92.3%). Assessment of PD-L1 expression was similar between histological and cytological samples (agreement rate = 92%). Sensitivity and diagnostic accuracy of EBUS-TBNA cytological specimens were 88.9% and 100%, respectively. Conclusions: The evaluation of PD-L1 expression in EBUS-TBNA cytological specimens is feasible and presents good reproducibility when compared with routine histological samples. EBUS-TBNA cytological samples could be used for the assessment of PD-L1 expression in patients with NSCLC as a minimally invasive approach in stage IV NSCLC cancer patients. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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