Identification of FOXP1 as a favorable prognostic biomarker and tumor suppressor in intrahepatic cholangiocarcinoma

Autor:	Chenwei Tang, Hongkai Zhuang, Huanjun Tong, Xiaopeng Yu, Jialu Chen, Qingbin Wang, Xiaowu Ma, Bingkun Wang, Yonglin Hua, Changzhen Shang, Zhaohui Tang
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Intrahepatic cholangiocarcinoma Immunohistochemistry Outcome prediction Protein biomarker Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	BMC Cancer, Vol 24, Iss 1, Pp 1-13 (2024)
Druh dokumentu:	article
ISSN:	1471-2407
DOI:	10.1186/s12885-024-11882-x
Popis:	Abstract Background Forkhead-box protein P1 (FOXP1) has been proposed to have both oncogenic and tumor-suppressive properties, depending on tumor heterogeneity. However, the role of FOXP1 in intrahepatic cholangiocarcinoma (ICC) has not been previously reported. Methods Immunohistochemistry was performed to detect FOXP1 expression in ICC and normal liver tissues. The relationship between FOXP1 levels and the clinicopathological characteristics of patients with ICC was evaluated. Finally, in vitro and in vivo experiments were conducted to examine the regulatory role of FOXP1 in ICC cells. Results FOXP1 was significantly downregulated in the ICC compared to their peritumoral tissues (p
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/edc83ac894c54efa8562c2f01e2f90fb Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.