| Autor: |
Anil U. Chopade, Manojkumar U. Chopade, Bhanu M. Chanda, Dilip D. Sawaikar, Kiran B. Sonawane, Mukund K. Gurjar |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Arabian Journal of Chemistry, Vol 9, Iss S2, Pp S1597-S1602 (2016) |
| Druh dokumentu: |
article |
| ISSN: |
1878-5352 |
| DOI: |
10.1016/j.arabjc.2012.04.027 |
| Popis: |
A synthesis of (±)-thia-calanolide A 3 has been successfully accomplished starting from 3,5-dimethoxythiophenol 4, in six steps in an overall yield of 4.5%. The key reaction involved Friedel–Crafts tigloylation of 5,7-dihydroxy-4-n-propyl thiocoumarin 6 employing an appropriate solvent of CS2–PhNO2 in a ratio of 7:3. In its biological evaluation for anti-HIV activity, (±)-thia-calanolide A 3 demonstrated comparatively less activity with calanolide A and its synthetic analogue aza-calanolide. Further, (±)-3 has been resolved by chiral HPLC to (+) and (−)-3. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
