| Autor: |
Muhammad Athar Abbasi, Seon-Mi Yu, Aziz-ur-Rehman, Sabahat Zahra Siddiqui, Song Ja Kim, Hussain Raza, Mubashir Hassan, Abdul Rehman Sadiq Butt, Syed Adnan Ali Shah, Sung-Yum Seo |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Toxicology Reports, Vol 6, Iss , Pp 897-903 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2214-7500 |
| DOI: |
10.1016/j.toxrep.2019.08.016 |
| Popis: |
In the study presented here, a novel chlorobenzylated bi-heterocyclic hybrid molecule (7) was synthesized and its structural confirmation was carried out by IR, 1H-NMR, 13C-NMR and CHN analysis data. This compound 7 was subjected to biological study with B16F10 mouse melanoma cells. The anti-proliferative results showed that 7 showed no significant toxicity at concentrations ranging of 0–44 μM. The treatment of B16F10 cells with 7 at aforementioned concentration range indicated that migration of cells was significantly lower than that of the control cells in a dose dependent manner. The possible migration inhibitory effect of these melanoma cells was further evaluated through gelatinolytic activity of MMP-2 and MMP-9 secreted from B16F10 cells. It was inferred from our results that 7 was not affecting the expression and activity of these enzymes. Some other zinc-dependent matrix metalloproteinases (MMPs) were involved in the inhibitory progression. Taken together, compound 7 inhibited migrations of B16F10 mouse melanoma cells. Therefore, it may deserve consideration as a potential agent for the treatment of cancer. Keywords: 2-Aminothiazole, Triazole, Anti-proliferation, Matrix metalloproteinase, Zymography |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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