| Autor: |
Shohei Kitayama, Teruhiko Makino, Kuniko Fujita, Shuichi Mori, Fumina Furukawa, Ko Kagoyama, Megumi Mizawa, Tadamichi Shimizu |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Skin Health and Disease, Vol 3, Iss 5, Pp n/a-n/a (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2690-442X |
| DOI: |
10.1002/ski2.269 |
| Popis: |
Abstract Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe cutaneous adverse reaction involving multiorgan failure, with a complex interaction of various drugs, human herpesvirus reactivation and immune abnormalities suggested as the aetiology. We herein present the case of a 70‐year‐old man with a one‐week history of fever, facial oedema, erythematous macules and purpura on his trunk and extremities. He had anti‐TIF1γ antibody‐positive dermatomyositis and was treated with prednisolone sodium succinate (20 mg/day). Three weeks earlier, he was treated with ganciclovir (250 mg/day) for 7 days to treat asymptomatic cytomegalovirus viraemia. Laboratory investigations revealed eosinophilia with atypical lymphocytes and elevated liver enzyme levels. A histological examination showed interface dermatitis with necrotic keratinocytes, perivascular infiltration of lymphocytes and eosinophils in the upper dermis and erythrocyte extravasation without vasculitis. A lymphocyte transformation test (LTT) was positive for ganciclovir (stimulation index: 260%; normal: |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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