| Autor: |
Irina I. Kapustina, Tatyana N. Makarieva, Alla G. Guzii, Anatoly I. Kalinovsky, Roman S. Popov, Sergey A. Dyshlovoy, Boris B. Grebnev, Gunhild von Amsberg, Valentin A. Stonik |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Marine Drugs, Vol 18, Iss 6, p 310 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1660-3397 |
| DOI: |
10.3390/md18060310 |
| Popis: |
Leptogorgins A–C (1–3), new humulane sesquiterpenoids, and leptogorgoid A (4), a new dihydroxyketosteroid, were isolated from the gorgonian Leptogorgia sp. collected from the South China Sea. The structures were established using MS and NMR data. The absolute configuration of 1 was confirmed by a modification of Mosher’s method. Configurations of double bonds followed from NMR data, including NOE correlations. This is the first report of humulane-type sesquiterpenoids from marine invertebrates. Sesquiterpenoids leptogorgins A (1) and B (2) exhibited a moderate cytotoxicity and some selectivity against human drug-resistant prostate cancer cells 22Rv1. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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