| Autor: |
Mehmet Maden, Merve Ider, Mehmet Erman Or, Banu Dokuzeylül, Erdem Gülersoy, Merve Cansu Kılıçkaya, Bengü Bilgiç, Murat Kaan Durgut, Semih İzmirli, Suleyman Serhat Iyigün, Deniz Zeynep Telci, Amir Naseri |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
BMC Veterinary Research, Vol 20, Iss 1, Pp 1-13 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1746-6148 |
| DOI: |
10.1186/s12917-024-04345-9 |
| Popis: |
Abstract Background Mitochondrial biogenesis (MB) induction has recently emerged as potential therapeutic approaches in kidney pathology and the mitochondria-targeted therapies should be investigated to improve treatment of animals with kidney diseases. This study aimed to investigate the effects of MB induction with sildenafil citrate on the cGMP/NO pathway, glomerular filtration, and reduction of kidney damage and fibrosis (TGF-β/SMAD pathway) in cats with acute on chronic kidney disease (ACKD). Thirty-three cats were divided into the non-azotemic (healthy) group (n:8) and the ACKD group (n:25), comprising different breeds, sexes, and ages. Sildenafil citrate was administered to the non-azotemic and ACKD groups (2.5 mg/kg, PO, q12 hours) for 30 days. Serum and urine NO, MDA, NGAL, KIM-1, TGF-β1, IL-18, FGF 23, PGC-1α and cGMP concentrations were measured. Results Serum cGMP concentrations increased (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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