Systemic redox imbalance along with increased serum sialic acid is prevalent in patients with active vitiligo: A study from a tertiary care teaching hospital of eastern India

Autor: Nilotpal Banerjee, Sanchaita Gayen, Dolanchampa Modak, Somenath Sarkar, Bibhuti Saha, Sumi Mukhopadhyay
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Indian Journal of Dermatology, Vol 64, Iss 2, Pp 97-100 (2019)
Druh dokumentu: article
ISSN: 0019-5154
1998-3611
DOI: 10.4103/ijd.IJD_448_17
Popis: Background: Vitiligo is one of the common depigmenting disorders causing disfigurement and affecting the quality of life. Redox imbalance is known to play a contributory role in melanocyte destruction. Serum sialic acid (SA) is an important marker of the acute-phase response and is associated with oxidative protein damage. Aim: The aim of this study was to analyze the status of oxidative stress markers and serum SA in vitiligo patients and to correlate the same with disease activity. Materials and Methods: The different oxidative stress parameters namely superoxide dismutase (SOD), malondialdehyde (MDA), and serum SA were measured spectrophotometrically using standard biochemical methodologies in all the study subjects. Results: Serum SOD and MDA values were higher in patients with active vitiligo (n = 23) as compared to stable vitiligo (n = 20) and healthy controls (n = 20). The MDA/SOD ratio was higher in patients with active vitiligo (P
Databáze: Directory of Open Access Journals
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje