Epidemiology of norovirus gastroenteritis in hospitalized children under five years old in western China, 2015–2019
| Autor: | Ran-Ran Cao, Xiao-Zhen Ma, Wan-Yi Li, Bao-Ning Wang, Yuan Yang, Hong-Ren Wang, Yu Kuang, Jiang-Zhou You, Zhong-Yi Zhao, Min Ren, Lin-Lin Zhou, Ming-Yuan Li |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Journal of Microbiology, Immunology and Infection, Vol 54, Iss 5, Pp 918-925 (2021) |
| Druh dokumentu: | article |
| ISSN: | 1684-1182 83610081 |
| DOI: | 10.1016/j.jmii.2021.01.002 |
| Popis: | Objectives: Norovirus is associated with one-fifth of all gastroenteritis cases, but basic epidemiological data is lacking, especially in developing countries. As long-term surveillance on norovirus gastroenteritis is scarce in western China, this study aims to update the epidemiological knowledge of norovirus gastroenteritis and to characterize the genotypes of norovirus strains. Methods: Stool samples were collected from hospitalized children under 5 years old with gastroenteritis in Chengdu, China. All samples were tested for norovirus as well as rotavirus, sapovirus, enteric adenovirus, and astrovirus by real-time RT-PCR. RdRp and VP1 genes were sequenced in norovirus-positive samples to investigate viral phylogenies. Results: Of the 1181 samples collected from 2015 to 2019, 242 (20.5%) were positive for norovirus.Among norovirus-positive cases, 65 cases had co-infection with another virus; norovirus/enteric adenovirus was most frequently detected (50.8%, 33/65). The highest positive rate was observed in children aged 13–18 months (23.7%, 68/287). Norovirus infection peaked in autumn (36.6%, 91/249), followed by summer (20.3%, 70/345). Pearson correlation analysis showed significant correlation between the norovirus-positive rate and humidity (r = 0.773, P |
| Databáze: | Directory of Open Access Journals |
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