| Autor: |
Valérie Marcil, Devendra Amre, Ernest G Seidman, François Boudreau, Fernand P Gendron, Daniel Ménard, Jean François Beaulieu, Daniel Sinnett, Marie Lambert, Emile Levy |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
PLoS ONE, Vol 10, Iss 2, p e0117238 (2015) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0117238 |
| Popis: |
Hepatocyte nuclear factor 4 alpha (HNF4α) is a transcription factor involved in the regulation of serum glucose and lipid levels. Several HNF4A gene variants have been associated with the risk of developing type 2 diabetes mellitus. However, no study has yet explored its association with insulin resistance and the cardiometabolic risk in children. We aimed to investigate the relationship between HNF4A genetic variants and the presence of metabolic syndrome (MetS) and metabolic parameters in a pediatric population.Our study included 1,749 French-Canadians aged 9, 13 and 16 years and evaluated 24 HNF4A polymorphisms that were previously identified by sequencing.Analyses revealed that, after correction for multiple testing, one SNP (rs736824; P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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