| Autor: |
Xue-Lian Qi, Kendyl R. Pennington, Christopher Banerjee, Fernando L. Vale, Sarah K. Bick, Dario J. Englot, Robert S. Turner, Christos Constantinidis, David T. Blake |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
STAR Protocols, Vol 3, Iss 1, Pp 101136- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2666-1667 |
| DOI: |
10.1016/j.xpro.2022.101136 |
| Popis: |
Summary: We present an experimental protocol to record neuronal activity during intermittent stimulation of nucleus basalis (NB), as macaque monkeys perform cognitive tasks. This protocol includes implantation of electrodes and generator devices to deliver electrical stimulation to NB using multiple approaches in monkeys. Direct stimulation of NB avoids peripheral cholinergic side effects, optimizes timing, and activates non-cholinergic projection neurons. We describe electrode preparation, surgery, and implantation for direct evaluation of how stimulation affects monkeys’ behavior and neuronal activity.For complete details on the use and execution of this profile, please refer to Qi et al. (2021). |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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