Cyclophosphamide treatment regulates the balance of functional/exhausted tumor-specific CD8+ T cells

Autor:	Aurélie Hanoteau, Coralie Henin, David Svec, Charlotte Bisilliat Donnet, Sébastien Denanglaire, Didier Colau, Pedro Romero, Oberdan Leo, Benoit Van den Eynde, Muriel Moser
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	cd8+ t cells cyclophosphamide effector function exhaustion tumor-specific immunity Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	OncoImmunology, Vol 6, Iss 8 (2017)
Druh dokumentu:	article
ISSN:	2162-402X 2162402X
DOI:	10.1080/2162402X.2017.1318234
Popis:	An important question is how chemotherapy may (re-)activate tumor-specific immunity. In this study, we provide a phenotypic, functional and genomic analysis of tumor-specific CD8+ T cells in tumor (P815)-bearing mice, treated or not with cyclophosphamide. Our data show that chemotherapy favors the development of effector-type lymphocytes in tumor bed, characterized by higher KLRG-1 expression, lower PD-1 expression and increased cytotoxicity. This suggests re-engagement of T lymphocytes into the effector program. IFN-I appears involved in this remodeling. Our findings provide some insight into how cyclophosphamide regulates the amplitude and quality of tumor-specific immune responses.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/c8345ee694324e43988a73ec92e52dc0 Zobrazit plný text záznamu View record in DOAJ