Importance of Standardizing Analytical Characterization Methodology for Improved Reliability of the Nanomedicine Literature

Autor: Shahriar Sharifi, Nouf N. Mahmoud, Elizabeth Voke, Markita P. Landry, Morteza Mahmoudi
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nano-Micro Letters, Vol 14, Iss 1, Pp 1-15 (2022)
Druh dokumentu: article
ISSN: 2311-6706
2150-5551
DOI: 10.1007/s40820-022-00922-5
Popis: Abstract Understanding the interaction between biological structures and nanoscale technologies, dubbed the nano-bio interface, is required for successful development of safe and efficient nanomedicine products. The lack of a universal reporting system and decentralized methodologies for nanomaterial characterization have resulted in a low degree of reliability and reproducibility in the nanomedicine literature. As such, there is a strong need to establish a characterization system to support the reproducibility of nanoscience data particularly for studies seeking clinical translation. Here, we discuss the existing key standards for addressing robust characterization of nanomaterials based on their intended use in medical devices or as pharmaceuticals. We also discuss the challenges surrounding implementation of such standard protocols and their implication for translation of nanotechnology into clinical practice. We, however, emphasize that practical implementation of standard protocols in experimental laboratories requires long-term planning through integration of stakeholders including institutions and funding agencies.
Databáze: Directory of Open Access Journals
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje