Is longer axial length protective of vision-threatening diabetic retinopathy across different ages? A multicenter cohort of 736 patients

Autor: Mingpeng Xu, Bo Li, Chenxin Li, Peiwei Chai, Qinghua Qiu, Zhi Zheng, Qian Chen, Dawei Luo, Xiaofang Xu, Chuandi Zhou
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: International Journal of Retina and Vitreous, Vol 10, Iss 1, Pp 1-9 (2024)
Druh dokumentu: article
ISSN: 2056-9920
DOI: 10.1186/s40942-024-00593-x
Popis: Abstract Purpose Vision-threatening diabetic retinopathy (VTDR) included severe non-proliferative diabetic retinopathy (NPDR), proliferative diabetic retinopathy (PDR) and clinically significant diabetic macular edema (DME). To compare the axial length (AL) and assess its influence on VTDR across different ages. Methods A retrospective cohort study. Medical chart review was performed in 736 consecutive patients with VTDR. The patients were divided into young (≤ 45 years) and elderly group (> 45 years) based on their age at the diagnosis of VTDR. After at least one year of standardized treatments, all eligible patients were followed up. The main outcome measures included the presence of tractional retinal detachment (TRD) involving foveal, final best-corrected visual acuity (BCVA), the development of neovascular glaucoma (NVG), and recurrent vitreous hemorrhage (VH) post-vitrectomy. ALs were compared between two age groups. The impact of AL on clinical outcomes was determined by logistic analyses after controlling for systemic parameters. Results The study included 144 patients ≤ 45 years and 592 patients > 45 years. Young patients had significantly longer AL than elderly participants (23.9 mm vs 23.0 mm, p
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