| Autor: |
Jiaye Liu, Yang Wang, Chunyang Mu, Meng Li, Kewei Li, Shan Li, Wenshuang Wu, Lingyao Du, Xiaoyun Zhang, Chuan Li, Wei Peng, Junyi Shen, Yang Liu, Dujiang Yang, Kaixiang Zhang, Qingyang Ning, Xiaoying Fu, Yu Zeng, Yinyun Ni, Zongguang Zhou, Yi Liu, Yiguo Hu, Xiaofeng Zheng, Tianfu Wen, Zhihui Li, Yong Liu |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-022-31928-7 |
| Popis: |
Pharmacological inhibition of the prolyl isomerase PIN1, highly expressed in cancer cells and cancer associated fibroblasts (CAF), has been proposed for cancer therapy. Here the authors report the design of a DNA-barcoded micellular system functionalized with antibodies targeting CAFs and a T cell recruiting aptamer to deliver the PIN1 inhibitor AG17724, showing antitumor response in preclinical models of pancreatic cancer. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full text from SpringerLink