Expression strategies for the efficient synthesis of antimicrobial peptides in plastids

Autor: Matthijs P. Hoelscher, Joachim Forner, Silvia Calderone, Carolin Krämer, Zachary Taylor, F. Vanessa Loiacono, Shreya Agrawal, Daniel Karcher, Fabio Moratti, Xenia Kroop, Ralph Bock
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-33516-1
Popis: Antimicrobial peptides (AMPs) are promising next-generation antibiotics, but are difficult to produce due to the toxicity to bacterial hosts. Here, the authors report the utilization of transplastomic tobacco plants for AMPs production without cytotoxic effects via inducible expression systems and fusions to cleavable carrier protein.
Databáze: Directory of Open Access Journals