| Autor: |
Wang Hui-Ting, Liu Chu-Feng, Tsai Tzu-Hsien, Chen Yung-Lung, Chang Hsueh-Wen, Tsai Ching-Yen, Leu Steve, Zhen Yen-Yi, Chai Han-Tan, Chung Sheng-Ying, Chua Sarah, Yen Chia-Hung, Yip Hon-Kan |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
Journal of Translational Medicine, Vol 10, Iss 1, p 145 (2012) |
| Druh dokumentu: |
article |
| ISSN: |
1479-5876 |
| DOI: |
10.1186/1479-5876-10-145 |
| Popis: |
Abstract Background Obesity is an important cardiovascular risk factor. This study tested the effect of obesity reduction on preserving left ventricular ejection fraction (LVEF) and attenuating inflammation, oxidative stress and LV remodeling in obese mice. Methods and results Eight-week-old C57BL/6 J mice (n=24) were equally divided into control (fed a control diet for 22 weeks), obesity (high-fat diet, 22 weeks), and obese reduction (OR) (high-fat diet, 14 weeks; then control diet, 8 weeks). Animals were sacrificed at post 22-week high-fat diet and the LV myocardium collected. Heart weight, body weight, abdominal-fat weight, total cholesterol level and fasting blood glucose were higher in obesity than in control and OR (all p Conclusion Impaired LVEF, enhanced LV remodeling, inflammation, fibrosis, oxidative stress and apoptosis were reversed by reduction in mouse obesity. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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