Influence of biochemical diagnosis of growth hormone deficiency on replacement therapy response and retesting results at adult height

Autor:	Giulia Rodari, E. Profka, F. Giacchetti, I. Cavenaghi, M. Arosio, C. Giavoli
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Medicine Science
Zdroj:	Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Druh dokumentu:	article
ISSN:	2045-2322
DOI:	10.1038/s41598-021-93963-6
Popis:	Abstract Isolated growth hormone deficiency (IGHD) is the most frequent endocrinological disorder in children with short stature, however the diagnosis is still controversial due to the scarcity of reliable diagnostic criteria and pre-treatment predictive factors of long term-response. To evaluate recombinant growth hormone (rGH) long-term response and retesting results in three different groups of children divided in accordance with the biochemical criteria of initial diagnosis. Height gain (∆HT) at adult height (AH) and retesting results were evaluated in 57 rGH treated children (M = 34, 59.6%) divided into 3 groups according to initial diagnosis: Group A (n = 25) with max GH peak at stimulation test
Databáze:	Directory of Open Access Journals
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