| Autor: |
Hidefumi Inaba, Hiroyuki Ariyasu, Hiroshi Iwakura, Chiaki Kurimoto, Yoko Ueda, Shinsuke Uraki, Ken Takeshima, Yasushi Furukawa, Shuhei Morita, Yoshiaki Nakayama, Takuya Ohashi, Hidefumi Ito, Yoshiharu Nishimura, Takashi Akamizu |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
BMC Endocrine Disorders, Vol 20, Iss 1, Pp 1-5 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1472-6823 |
| DOI: |
10.1186/s12902-020-0498-5 |
| Popis: |
Abstract Background Autoimmune polyglandular syndrome type 2 (APS-2) is a rare and complex clinical entity, and little is known about its etiology and progression. Case presentation A 52-year-old woman with autoimmune hepatitis (AIH) and bronchial asthma was diagnosed with APS-2; autoimmune Addison’s disease (AD), and Hashimoto’s thyroiditis (HT), and she underwent prednisolone (PSL) treatment. Five months later, she presented ptosis and was diagnosed with thymoma-associated myasthenia gravis (MG). Thymectomy and PSL treatment with immuno-suppressants appeared to ameliorate MG, AD, AIH, HT, and bronchial asthma. HLA typing analysis revealed that the patient had susceptible HLA alleles to MG, AIH, and HT in a Japanese population. Conclusions This case suggests common endocrinological and autoimmune aspects of APS-2 and AIH with thymoma-associated MG, which are considered to be extremely rare complications. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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