A CLINICAL CASE OF SYSTEMIC JUVENILE ARTHRITIS COMPLICATED BY RECURRENT MACROPHAGE ACTIVATION SYNDROME AND CHRONIC OSTEOMYELITIS OF THE CLAVICLE
| Autor: | M. I. Kaleda, I. P. Nikishina, S. V. Arsenyeva |
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| Jazyk: | ruština |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Научно-практическая ревматология, Vol 56, Iss 1, Pp 107-112 (2018) |
| Druh dokumentu: | article |
| ISSN: | 1995-4484 1995-4492 |
| DOI: | 10.14412/1995-4484-2018-107-112 |
| Popis: | The paper describes a clinical case of severe systemic juvenile idiopathic arthritis (JIA) in a child with an early disease onset, which is resistant to multicomponent therapy (glucocorticoids, methotrexate, the tumor necrosis factor-α inhibitor etanercept), and the successful use of the anti-interleukin 6 receptor monoclonal antibody tocilizumab with the achievement of sustained (30-month) drug remission. The therapy with tocilizumab was accompanied by unpredictable adverse events (chronic osteomyelitis of the clavicle, macrophage activation syndrome) and their timely treatment permitted avoidance of life-threatening consequences. The presented case shows difficulties in the follow-up of patients with systemic JIA in clinical practice, requiring alertness to the risk of infectious complications and development of macrophage activation syndrome. |
| Databáze: | Directory of Open Access Journals |
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