Response to dabrafenib plus trametinib on a rare BRAF mutation (V600_W604 deletion–insertion R) in an advanced non‐small cell lung cancer patient

Autor:	Akiko Tamura, Ryoko Inaba Higashiyama, Tatsuya Yoshida, Yaya Satozono, Yuichiro Ohe
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	BRAF mutation BRAF V600_W604 deletion–insertion R comprehensive genomic profiling dabrafenib plus trametinib lung adenocarcinoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Thoracic Cancer, Vol 15, Iss 18, Pp 1454-1456 (2024)
Druh dokumentu:	article
ISSN:	1759-7714 1759-7706
DOI:	10.1111/1759-7714.15330
Popis:	Abstract Although dabrafenib plus trametinib has been approved for BRAF V600E mutation positive advanced non‐small cell lung cancer (NSCLC), data on its efficacy against uncommon BRAF mutations are still limited due to their rare frequency. We report a case of 70‐year‐old woman with BRAF V600_W604 deletion–insertion R‐positive stage IVA lung adenocarcinoma, who was successfully treated with dabrafenib plus trametinib. Herein, we discuss the oncogenic role of uncommon BRAF mutations and highlight the importance of performing comprehensive genomic profiling on patients without any targetable gene alterations in companion diagnostics.
Databáze:	Directory of Open Access Journals
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