Evaluation of type 1 diabetes’ partial clinical remission after three years of heterologous adipose tissue derived stromal/stem cells transplantation associated with vitamin D supplementation

Autor: Isabella Sued Leão, Joana Rodrigues Dantas, Débora Baptista Araújo, Maria Eduarda Nascimento Ramos, Karina Ribeiro Silva, Leandra S. Batista, Maria de Fátima Carvalho Pereira, Ronir Raggio Luiz, César Cláudio da Silva, Angelo Maiolino, Carmen Lúcia Kuniyoshi Rebelatto, Débora Regina Daga, Alexandra Cristina Senegaglia, Paulo Roberto Slud Brofman, José Egídio Paulo de Oliveira, Lenita Zajdenverg, Melanie Rodacki
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Diabetology & Metabolic Syndrome, Vol 16, Iss 1, Pp 1-9 (2024)
Druh dokumentu: article
ISSN: 1758-5996
06687334
DOI: 10.1186/s13098-024-01302-2
Popis: Abstract Background Mesenchymal stem cell infusion and vitamin D supplementation may have immunomodulatory actions that could prolong the preservation of residual insulin secretion in patients with type 1 diabetes (T1D). Intervention with these agents after onset of T1D could favor the development of a remission phase, with potential clinical impact. We aimed to compare the presence of clinical remission (CR), glycemic control and daily insulin requirement at 6, 12, 18, 24 and 36 months after the diagnosis of T1D using IDAA1c in patients who received therapy with adipose tissue-derived mesenchymal stem cell (ASC) infusion and vitamin D supplementation and a control group. Methods: This retrospective cohort study analyzed data from the medical records of patients with T1D diagnosed between 15 and 40 years. Partial CR was defined as an IDAA1c index
Databáze: Directory of Open Access Journals
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