| Autor: |
Marta Scorsetti, Pierina Navarria, Luca Cozzi, Elena Clerici, Luisa Bellu, Davide Franceschini, Antonio Marco Marzo, Ciro Franzese, Valter Torri, Giacomo Reggiori, Francesca Lobefalo, Luca Raspagliesi, Luca Attuati, Federico Pessina, Andrea Franzini, Piero Picozzi, Stefano Tomatis |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Radiation Oncology, Vol 18, Iss 1, Pp 1-11 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1748-717X |
| DOI: |
10.1186/s13014-023-02216-5 |
| Popis: |
Abstract Background Comparative prospective data regarding different radiosurgery (SRS) modalities for treating brain metastases (BMs) from solid tumors are not available. To investigate with a single institute phase III randomized trial whether SRS executed with linac (Arm-B) is superior to a dedicated multi-source gamma-ray stereotactic platform (Arm-A). Methods Adults patients with 1–4 BMs from solid tumors up to 30 mm in maximum diameter were randomly assigned to arms A and B. The primary endpoint was cumulative incidence of symptomatic (grade 2–3) radionecrosis (CIRN). Secondary endpoints were local progression cumulative incidence (CILP), distant brain failure, disease-free survival (DFS), and overall survival (OS). Results A total of 251 patients were randomly assigned to Arm-A (121) or Arm-B (130). The 1-year RN cumulative incidence was 6.7% in whole cohort, 3.8% (95% CI 1.9–7.4%) in Arm-B, and 9.3% (95% CI 6.2–13.8%) in the Arm-A (p = 0.43). CIRN was influenced by target volume irradiated only for the Arm-A (p < |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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