Synthesis of Carvone-Derived 1,2,3-Triazoles Study of Their Antioxidant Properties and Interaction with Bovine Serum Albumin

Autor:	Armen S. Galstyan, Armen I. Martiryan, Karine R. Grigoryan, Armine G. Ghazaryan, Melanya A. Samvelyan, Tariel V. Ghochikyan, Valentine G. Nenajdenko
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	carvone 1 2 3-triazole click chemistry acetylene antioxidant activity bovine serum albumin Organic chemistry QD241-441
Zdroj:	Molecules, Vol 23, Iss 11, p 2991 (2018)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules23112991
Popis:	Natural L-carvone was utilized as a starting material for an efficient synthesis of some terpenyl-derived 1,2,3-triazoles. Chlorination of carvone, followed by nucleophilic substitution with sodium azide resulted in the preparation of 10-azidocarvone. Subsequent CuAAC click reaction with propargylated derivatives provided an efficient synthetic route to a set of terpenyl-derived conjugates with increased solubility in water. All investigated compounds exhibit high antioxidant activity, which is comparable with that of vitamin C. It was also found that serum albumin and the terpenyl-1,2,3-triazoles hybrids spontaneously undergo reversible binding driven by hydrophobic interactions, suggesting that serum albumin can transport the target triazoles.
Databáze:	Directory of Open Access Journals
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