Molecular pathogenesis of Rocky Mountain spotted fever: a brief review
| Autor: | Peter Uteh Upla, Bashiru Sani, Naja’atu Shehu Hadi, Fatima Yusuf Al-Mustapha, Kabiru Shuaibu |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | IMC Journal of Medical Science, Vol 16, Iss 1, Pp 1-6 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2519-1721 2519-1586 |
| DOI: | 10.55010/imcjms.16.010 |
| Popis: | Rocky Mountain spotted fever (RMSF) is a bacterial infection caused by Rickettsia, a diverse group of small Gram-negative rod-shaped α-proteobacteria, and obligates intracellular pathogens, which are free-living in hosts' cell cytoplasm and are transmitted to humans by arthropod vectors. It is the most acute rickettsial diseases known to human, with significant death rates of over 20–30%. They are distinguished by a strictly intracellular position which has, for long, delayed their comprehensive study. This article attempts primarily to focus on the mechanisms of Rickettsia-host cell interactions and the underlying molecular pathogenesis of RMSF. IMC J Med Sci 2022; 16(1): 004. DOI: https://doi.org/10.55010/imcjms.16.010 *Correspondence: Bashiru Sani, Department of Microbiology, Federal University of Lafia, Nasarawa State, Nigeria. Email: bashmodulus@gmail.com |
| Databáze: | Directory of Open Access Journals |
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