Impact of intrafraction changes in delivered dose of the day for prostate cancer patients treated with stereotactic body radiotherapy via MR-Linac

Autor: Jennifer Dang, Vickie Kong, Winnie Li, Inmaculada Navarro, Jeff D. Winter, Victor Malkov, Alejandro Berlin, Charles Catton, Jerusha Padayachee, Srinivas Raman, Padraig Warde, Peter Chung
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Technical Innovations & Patient Support in Radiation Oncology, Vol 23, Iss , Pp 41-46 (2022)
Druh dokumentu: article
ISSN: 2405-6324
DOI: 10.1016/j.tipsro.2022.08.005
Popis: Purpose: The purpose of this study is to evaluate the impact of intrafraction pelvic motion by comparing the adapted plan dose (APD) and the computed delivered dose of the day (DDOTD) for patients with prostate cancer (PCa) treated with SBRT on the MR-Linac. Methods: Twenty patients with PCa treated with MR-guided adaptive SBRT were included. A 9-field IMRT distribution was adapted based on the anatomy of the day to deliver a total prescription dose of 3000 cGy in 5 fractions to the prostate plus a 5 mm isotropic margin. Prostate, bladder, and rectum were re-contoured on the MR-image acquired during treatment delivery (MRBO). DDOTD was computed by propagating the dose from the daily adapted plan generated during treatment onto the MRBO. Results: Target coverage was met for all fractions, however, computed DDOTD was significantly less than the APD (p
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