Primate-specific transposable elements shape transcriptional networks during human development

Autor: Julien Pontis, Cyril Pulver, Christopher J. Playfoot, Evarist Planet, Delphine Grun, Sandra Offner, Julien Duc, Andrea Manfrin, Matthias P. Lutolf, Didier Trono
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-34800-w
Popis: The human genome harbors more than 4.5 million transposable element (TE)-derived insertions, the result of recurrent waves of invasion and internal propagation. Here they show that TEs belonging to evolutionarily recent subfamilies go on to regulate later stages of human embryonic development, notably conditioning the expression of genes involved in gastrulation and early organogenesis.
Databáze: Directory of Open Access Journals