Comparison of Catalytic Effect of Alkali and Alkaline Earth Metals Hydrogen Sulfate: As the Promoter for an Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones under Solvent-Free Conditions

Autor: Ahmad Shaabani, Ayoob Bazgir, Sakineh Arab Ameri, Masoumeh Sharifi Kiasaraie, Sima Samadi
Jazyk: angličtina
Rok vydání: 2005
Předmět:
Zdroj: Iranian Journal of Chemistry & Chemical Engineering, Vol 24, Iss 3, Pp 67-71 (2005)
Druh dokumentu: article
ISSN: 1021-9986
Popis: Alkali and alkaline earth metals hydrogen sulfate catalyzed the one-pot three component condensation reactions of aldehydes, 1,3-dicarbonyl compounds and urea or thiourea under solvent-free conditions leading to 3,4-dihydropyrimidin-2(1H)-ones in high yields at 80 °C. Our results showed that Biginelli reaction not only is pH dependent, but the cation of catalyst plays an important role.
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