Evaluation of hela cell lineage response to β radiation from Holmium-166 embedded in ceramic seeds
| Autor: | Eduardo Sarmento Valente, Ethel Mizrahy Cuperschmid, Tarcisio Passos Ribeiro de Campos |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Brazilian Archives of Biology and Technology, Vol 54, Iss 5, Pp 957-964 (2011) |
| Druh dokumentu: | article |
| ISSN: | 1516-8913 1678-4324 20327498 |
| DOI: | 10.1590/S1516-89132011000500013 |
| Popis: | This work studied the effects of β radiation of Ho-166 embedded in ceramic seeds on HeLa cells. Methodology consisted in the production of ceramic seeds with holmium-165 by sol-gel route. Chemical and physical characterizations of the seeds were performed. Subsequently, nuclear characterization was performed by gamma spectrometry. Experimental and theoretical activities were defined and initial dose rate were evaluated by MIRD (Medical Internal Radiation Dose Committee) methodology. The seeds were placed in confluent culture flasks and remained for six radionuclide half-lives. Biological results were represented by a clean 6 mm diameter area around the seed where the tumour cells were killed. The initial dose rate was 15.5 Gy. h-1. The maximum absorbed dose was 591.3 Gy. The features of the Ho-166 seeds suggested that such ceramic seeds were suitable for high dose rate brachytherapy. |
| Databáze: | Directory of Open Access Journals |
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