| Autor: |
Shahzad eRaza, Stella C Lymberis, Raquel eCiervide, Deborah eAxelrod, Maria eFenton-Kerimian, Chiara eMagnolfi, Barry eRosenstein, J. Keith eDeWyngaert, Silvia C Formenti |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
Frontiers in Oncology, Vol 2 (2012) |
| Druh dokumentu: |
article |
| ISSN: |
2234-943X |
| DOI: |
10.3389/fonc.2012.00044 |
| Popis: |
Purpose: Limited information is available comparing toxicity of accelerated radiotherapy (RT) to those of standard fractionation RT for early stage breast cancer, after breast conserving surgery. We report early and late toxicities of two prone regimens of accelerated intensity modulated radiation therapy (IMRT) with a concomitant boost (CB) to the tumor bed delivered over 3 or 5 weeks as compared to standard 6 week RT with a sequential electron boost.Methods: From 2/2003 to 12/2007, 169 consecutive patients with Stage I-II breast cancer were offered the choice to undergo prone RT with either: a 6 weeks standard RT regimen of 46 Gy/23 fractions (fx) to the whole breast (WB), followed by a14 Gy sequential boost (SB) to the tumor bed (6wSB) ; a 5 week regimen of 50 Gy to WB a with a IMRT CB of 6.25 Gy in 25 fx (5wCB); or a 3 week protocol of 40.5 Gy to WB with an IMRT CB of 7.5 Gy in 15 fx (3wCB). These regimens were estimated as biologically equivalent, based on alpha/beta=4 for tumor control. Toxicities were reported using RTOG and LENT/SOMA scoring.Results: 51/169 patients chose standard 6wSB, 28 selected 5wCB, and 90 enrolled in 3wCB protocol. Maximum acute toxicity was grade 3 dermatitis in 4% of the patients in the 6wSB compared 1% in 3wCB. In general, acute complications (breast pain, fatigue, and dermatitis) were significantly less in the 3wCB than in the other schedules (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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