METABOLIC THERAPY FOR PATIENTS WITH COEXISTING VISCERAL AND PERIODONTAL DISEASES
| Autor: | I. A. Gorbacheva, Yu. A. Sycheva, L. Yu. Orekhova |
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| Jazyk: | ruština |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, Vol 24, Iss 4, Pp 55-63 (2017) |
| Druh dokumentu: | article |
| ISSN: | 1607-4181 2541-8807 |
| DOI: | 10.24884/1607-4181-2017-24-4-55-63 |
| Popis: | Introduction. Nowadays, many evidences about interrelation of inflammatory defeats of parodont and various internal diseases have been collected. Universal molecular and cellular deviations, violations of redox metabolism, pathological activation of apoptosis promote development and progressing of many somatic diseases and the inflammatory diseases of parodont associated with them.The objective is to evaluate the efficacy of metabolic therapy in patients with coexisting visceral and periodontal diseases.Materials and methods. 909 patients with visceral diseases associated with generalized periodontitis were examined totally. Group I consisted of 100 patients with chronic infection sites of different localization. Group II consisted of 100 patients with cardiovascular diseasesю Patients from group I and II were divided into two sub-groups, they were prescribed to take metabolic drugs – mexidol (ethylmethylhydroxypyridine succinate) or сycloferon (meglumine acridonacitate) and mildronate (meldonium dehydrate) or cytoflavin (drug succinic acid). Intensity of free radical oxidation in organism was assessed by the products of lipid peroxidation; oxidation of thiol-containing compounds – proteins and low-molecular thiols – was assessed by using direct and back amperometric titration; apoptosis was studied on the model of lymph cells using flow cytometry (Annexin V – FITC); the status of periodontium was assessed with definition of the periodontal index (PI) and community periodontal index of treatment needs (CPITN).Results. The activity of lipid peroxidation and free radical oxidation of thiols (р |
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