| Autor: |
Xiuwen Liang, Tingting He, Lihong Gao, Libo Wei, Di Rong, Yu Zhang, Yu Liu |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
PPAR Research, Vol 2022 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1687-4765 |
| DOI: |
10.1155/2022/2054876 |
| Popis: |
Both rs1801133 mutation on Methylenetetrahydrofolate reductase (MTHFR) gene and transcription factor peroxisome proliferator-activated gamma (PPARG) have been associated with plasma homocysteine (Hcy) levels and hypertension. However, their role in H-type hypertension remains unclear. In this study, we first tested the association between rs1801133 genotypes and Hcy level in H-type hypertension using clinical profiles collected from 203 patients before and after the treatment using enalapril maleate and folic acid tablets (EMFAT). Then, we constructed a literature-based pathway analysis to explore the role of the rs1801133-PPARG signaling pathway in H-type hypertension and its treatment. Although presented similar blood pressure, the patients with TT genotype of rs1801133 were much younger (p value |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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