The Prognostic Significance of CD47, CD68, and CD163 Expression Levels and Their Relationship with MLR and MAR in Locally Advanced and Oligometastatic Nasopharyngeal Carcinoma

Autor:	Asim Armagan Aydin, Ramazan Oguz Yuceer, Senay Yildirim, Ahmet Unlu, Erkan Kayikcioglu, Murat Kocer
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	nasopharyngeal carcinoma CD47 CD68 CD163 tumor-associated macrophages monocyte-to-lymphocyte ratio Medicine (General) R5-920
Zdroj:	Diagnostics, Vol 14, Iss 23, p 2648 (2024)
Druh dokumentu:	article
ISSN:	2075-4418
DOI:	10.3390/diagnostics14232648
Popis:	Background: This study aimed to assess the prognostic and predictive implications of CD47, CD68, and CD163, biomarkers of tumor-associated macrophages (TAMs), on the treatment efficacy and clinical outcomes of nasopharyngeal carcinoma (NPC). Additionally, the prognostic value of TAM-related indices, such as the monocyte-to-lymphocyte ratio (MLR) and monocyte-to-albumin ratio (MAR), was evaluated. Methods: A retrospective cohort of 54 patients with locally advanced or oligometastatic NPC treated with concurrent chemoradiotherapy (CCRT), with or without induction chemotherapy, was analyzed. Patients were categorized based on the cumulative expression scores for CD47, CD68, and CD163: negative/low (0–3 points) and high (4–6 points). MLR and MAR were also stratified as low MLR (
Databáze:	Directory of Open Access Journals
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