A late endosome signaling hub that couples PI3Kα and WNT/β-catenin signaling in breast cancer

Autor:	Samuel J. Rodgers, Sabryn A. Hamila, Christina A. Mitchell, Lisa M. Ooms
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	inpp4b pik3ca wnt/β-catenin late endosome cell proliferation Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Molecular & Cellular Oncology, Vol 8, Iss 4 (2021)
Druh dokumentu:	article
ISSN:	2372-3556 23723556
DOI:	10.1080/23723556.2021.1954470
Popis:	AKT is the central phosphoinositide 3-kinase (PI3K) signaling effector, however, PIK3CA (p110α subunit of PI3Kα)-mutant estrogen receptor-positive (ER+) breast cancers exhibit minimal AKT activation and the downstream signaling is poorly characterized. We discovered that a subset of PIK3CA-mutant ER+ breast cancers exhibit increased inositol polyphosphate 4-phosphatase type II (INPP4B) expression, which promotes late endosome formation and glycogen synthase kinase 3 beta (GSK3β) trafficking, leading to enhanced Wingless–related integration site (WNT)/catenin beta 1 (β-catenin) activation.
Databáze:	Directory of Open Access Journals
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