| Autor: |
Anton H van Kaam, Wes Onland, Ruud W van Leuteren, Tomasz Szczapa, G Jeroen Hutten, Maria Wilinska, Thomas Bachman, Katarzyna Wroblewska-Seniuk, Karolina Chojnacka, Beata Loniewska, Karolina Olszanska, Beata Rzepecka Weglarz, Katarzyna Janusz, Pawel Piwowarczyk |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
BMJ Paediatrics Open, Vol 8, Iss 1 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2399-9772 |
| DOI: |
10.1136/bmjpo-2024-002583 |
| Popis: |
Objective This study aims to evaluate the performance of the fabian-Predictive-Intelligent-Control-of-Oxygenation (PRICO) system for automated control of the fraction of inspired oxygen (FiO2).Design Multicentre randomised cross-over study.Setting Five neonatal intensive care units experienced with automated control of FiO2 and the fabian ventilator.Patients 39 infants: median gestational age of 27 weeks (IQR: 26–30), postnatal age 7 days (IQR: 2–17), weight 1120 g (IQR: 915–1588), FiO2 0.32 (IQR: 0.22–0.43) receiving both non-invasive (27) and invasive (12) respiratory support.Intervention Randomised sequential 24-hour periods of automated and manual FiO2 control.Main outcome measures Proportion (%) of time in normoxaemia (90%–95% with FiO2>0.21 and 90%–100% when FiO2=0.21) was the primary endpoint. Secondary endpoints were severe hypoxaemia (98% with FiO2>0.21) and prevalence of episodes ≥60 s at these two SpO2 extremes.Results During automated control, subjects spent more time in normoxaemia (74%±22% vs 51%±22%, p95% with FiO2>0.21 (16%±19% vs 35%±24%) p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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