| Autor: |
Dimitrov Ivan, Atanasova Mariana |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Cybernetics and Information Technologies, Vol 20, Iss 6, Pp 175-184 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1314-4081 |
| DOI: |
10.2478/cait-2020-0071 |
| Popis: |
Allergenicity of proteins is a subtle property encoded in their structures. The prediction of allergenicity of novel proteins saves time and resources for subsequent experimental work. In the host antigen-presenting cells, the allergens are processed as antigens by the means of Human Leukocyte Antigens (HLA) class II proteins. Sometimes, people allergic to a given protein show allergic reaction to a different protein, even when the two proteins have different routes of exposure. This phenomenon is termed cross-reactivity. Here, we describe a server for allergenicity and cross-reactivity prediction based on the abilities of allergenic proteins to generate binders to HLA class II proteins. The generated peptides are compared to HLA binders originating from known allergens. As a result, the server returns a list of common binders, origin proteins, and species. Different species generate common HLA binders and this determines their cross-reactivity. The server is named AllerScreener and is freely accessible at: http://www.ddg-pharmfac.net/AllerScreener. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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