Targeting the two-pore channel 2 in cancer progression and metastasis
| Autor: | Kathryn A. Skelding, Daniel L. Barry, Danielle Z. Theron, Lisa F. Lincz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Exploration of Targeted Anti-tumor Therapy, Vol 3, Iss 1 (2022) |
| Druh dokumentu: | article |
| ISSN: | 2692-3114 21461546 |
| DOI: | 10.37349/etat.2022.00072 |
| Popis: | The importance of Ca2+ signaling, and particularly Ca2+ channels, in key events of cancer cell function such as proliferation, metastasis, autophagy and angiogenesis, has recently begun to be appreciated. Of particular note are two-pore channels (TPCs), a group of recently identified Ca2+-channels, located within the endolysosomal system. TPC2 has recently emerged as an intracellular ion channel of significant pathophysiological relevance, specifically in cancer, and interest in its role as an anti-cancer drug target has begun to be explored. Herein, an overview of the cancer-related functions of TPC2 and a discussion of its potential as a target for therapeutic intervention, including a summary of clinical trials examining the TPC2 inhibitors, naringenin, tetrandrine, and verapamil for the treatment of various cancers is provided. |
| Databáze: | Directory of Open Access Journals |
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