| Autor: |
Omar Z Ameer, Rochelle eBoyd, Mark eButlin, Alberto P Avolio, Jacqueline Kathleen Phillips |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
Frontiers in Physiology, Vol 6 (2015) |
| Druh dokumentu: |
article |
| ISSN: |
1664-042X |
| DOI: |
10.3389/fphys.2015.00150 |
| Popis: |
Increased stiffness of large arteries in chronic kidney disease (CKD) has significant clinical implications. This study investigates the temporal development of thoracic aortic dysfunction in a rodent model of CKD, the Lewis polycystic kidney (LPK) rat. Animals aged 12 and 18 weeks were studied alongside age-matched Lewis controls (total n=94). LPK rodents had elevated systolic blood pressure, left ventricular hypertrophy and progressively higher plasma creatinine and urea. Relative to Lewis controls, LPK exhibited reduced maximum aortic vasoconstriction (Rmax) to noradrenaline at 12 and 18 weeks, and to K+ (12 weeks). Sensitivity to noradrenaline was greater in 18-week-old LPK versus age matched Lewis (effective concentration 50%: 24×10-9 ± 78×10-10 vs. 19×10-8 ± 49×10-9, P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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